Asset Details
Do you wish to reserve the book?
Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial
Do you wish to request the book?
Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial
2015
Overview
Serum zinc level might be related to pathogenesis of febrile seizure (FS). The purpose of this study was to evaluate efficacy and safety of oral zinc supplementation on FS recurrence prevention in non-zinc-deficient children.
In a randomized clinical study, one hundred 18 to 60 mo old children with normal zinc level with first simple FS were referred to Shahid Sadoughi Hospital, Yazd, Iran from May 2012 to June 2013, were randomly assigned to two groups to receive 2 mg/kg/d zinc sulfate for six consecutive months or placebo as control group and were followed up for 1 y for FS recurrence.
41 girls and 59 boys with mean age of 2.47 ± 1.01 y were evaluated. Race, mean weight, height and body fat were similar in both groups. FS recurrence occurred in 19 children (38%) in the control group [95% confidence interval (CI): 19.45%–53.95%] and in 11 children (22%) in the zinc sulfate (95% CI: 57.47%–89.13%) groups, respectively; and the zinc group had lower FS recurrence (P = 0.03). The mean serum zinc level before intervention was lower in children with FS recurrence (72.43 ± 14.58 μg/dL versus 96.33 ± 12.69 μg/dL, P = 0.04).
Gastrointestinal side effects (vomiting in five children, heartburn in two children and abdominal pain in one child) were seen in 16% of the zinc group and vomiting occurred in two children (4%) in control group and frequency of adverse events was similar in the two groups (P = 0.1).
Zinc supplementation should be considered as effective and safe in prevention of FS recurrence.
•Efficacy of zinc sulfate on febrile seizure recurrence prevention was evaluated.•Febrile seizure recurrence was lower in children who received zinc supplement.•No serious or life-threatening side effects were observed in zinc group.•Children with febrile seizure recurrence had lower serum zinc levels.•Zinc can be used as an effective drug in prevention of febrile seizure recurrence.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ boys
/ Child
/ Children
/ Dietary Supplements - adverse effects
/ Epilepsy
/ Female
/ Fever
/ Gastroenterology and Hepatology
/ girls
/ Humans
/ Infant
/ Iran
/ Male
/ pain
/ placebos
/ Seizures, Febrile - prevention & control
/ Studies
/ Sulfates
/ Trace Elements - adverse effects
/ Trace Elements - therapeutic use
/ vomiting
/ Zinc
