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Locally Synchronized Synaptic Inputs
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Journal Article
Locally Synchronized Synaptic Inputs
2012
Overview
Synaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor-dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Brain
/ CA3 Region, Hippocampal - cytology
/ CA3 Region, Hippocampal - physiology
/ Calcium
/ Dendritic Spines - physiology
/ Dendritic Spines - ultrastructure
/ Excitatory Postsynaptic Potentials
/ Fundamental and applied biological sciences. Psychology
/ geometry
/ Imaging
/ Mice
/ Neurons
/ Pyramidal Cells - physiology
/ Rats
/ Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
/ Receptors, N-Methyl-D-Aspartate - metabolism
/ Rodents
/ Somatosensory Cortex - cytology
/ Somatosensory Cortex - physiology
/ Spine
