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An Update on Self-Amplifying mRNA Vaccine Development
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An Update on Self-Amplifying mRNA Vaccine Development
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Journal Article
An Update on Self-Amplifying mRNA Vaccine Development
2021
Overview
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
