Asset Details
Do you wish to reserve the book?
A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication
Do you wish to request the book?
A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication
2025
Overview
RNA interference (RNAi) and autophagy are two pivotal biological processes that regulate virus replication. This study explored the complex relationship between autophagy and RNAi in controlling influenza virus replication. Initially, we reported that influenza virus (H9N2) infection increases the viral load and the expression of autophagy markers while inhibiting the RNAi pathway. Subsequent studies employing autophagy enhancer and inhibitor treatments confirmed that avian influenza virus (AIV, H9N2) promotes viral replication by enhancing autophagy pathways. Further analysis revealed that ATG7, an autophagy protein, can interact with dicer to affect its antiviral functions. Finally, we discovered that infection with other avian RNA viruses, including infectious bursal disease virus (IBDV) and infectious bronchitis virus (IBV), induced the upregulation of ATG7, which blocked the RNAi pathway to facilitate virus replication. Our findings suggested that virus infection might trigger the upregulation of autophagy and downregulation of the RNAi pathway, revealing a complex interaction between these two biological processes in the defence against viral replication.
Publisher
Springer International Publishing,Springer Nature B.V,Springer
Subject
/ ATG7
/ Autophagy-Related Protein 7 - genetics
/ Autophagy-Related Protein 7 - metabolism
/ Biomedical and Life Sciences
/ birds
/ DEAD-box RNA Helicases - metabolism
/ Dicer
/ Dogs
/ H9N2
/ Humans
/ Infectious bronchitis virus - physiology
/ Infectious bursal disease virus
/ Infectious bursal disease virus - physiology
/ Influenza A Virus, H9N2 Subtype - physiology
/ Madin Darby Canine Kidney Cells
/ Original
/ Ribonuclease III - metabolism
/ RNA
/ RNAi
/ Viruses
