Journal Article

Serum C-Reactive Protein-to-Body Mass Index Ratio Predicts Overall Survival in Patients With Resected Colorectal Cancer

Meng, Yongsheng, Lai, Hao, Mo, Xianwei, Liu, Haizhou, Huang, Lingxu, Zhong, Huage, Huang, Xiaoliang, Zhang, Lihua, Liang, Dingyu, Tang, Weizhong, Liu, Jungang, Wei, Chunyin

2021

Overview

Background and Purpose: Systemic inflammation and nutritional status have been shown to be associated with the prognosis of colorectal cancer. The purpose of this study was to evaluate the impact of the serum C-reactive protein-to-body mass index ratio on the prognosis of patients with curatively resected colorectal cancer. Methods: We conducted a retrospective analysis of a database of 2,471 eligible patients with colorectal cancer who underwent curative resection at our hospital between 2004 and 2019. The optimal cut-off for CPR-to-BMI ratio was determined using maximally selected rank statistics. Patients were divided into 2 groups according to the cut-off value of the serum C-reactive protein-to-body mass index ratio. Kaplan-Meier curves and Cox regression analysis were used to compare overall survival. A two-sided P-value < 0.05 was considered statistically significant. Results: The proportion of patients with a high C-reactive protein-to-body mass index ratio increased with increasing age, male sex, right-sided colon cancer, poorly differentiated tumors, advanced-stage disease, local/distant metastases, tumor–node–metastasis stage, and microsatellite instability. In subgroup analysis according to tumor–node–metastasis stage, the overall survival of the high C-reactive protein-to-body mass index ratio group was significantly shorter than that of the low C-reactive protein-to-body mass index ratio group (P < 0.001). Multivariate analysis identified age, differentiation, tumor–node–metastasis stage, carcinoembryonic antigen level, and the C-reactive protein-to-body mass index ratio as independent poor prognostic factors for overall survival. Conclusions: The C-reactive protein-to-body mass index ratio predicts the prognosis of patients with curatively resected colorectal cancer and is an independent risk factor for overall survival in patients with colorectal cancer.

• Publisher: SAGE Publications,Sage Publications Ltd,SAGE Publishing
• Subject: Adult / Age Factors / Aged / Body Mass Index / C-reactive protein / C-Reactive Protein - metabolism / Carcinoembryonic antigen / Carcinoembryonic Antigen - blood / Colon cancer / Colorectal cancer / Colorectal Neoplasms - blood / Colorectal Neoplasms - pathology / Colorectal Neoplasms - physiopathology / Colorectal Neoplasms - surgery / Female / Humans / Kaplan-Meier Estimate / Male / Medical prognosis / Metastases / Metastasis / Microsatellite instability / Middle Aged / Multivariate analysis / Neoplasm Grading / Neoplasm Staging / Nutritional Status / Odds Ratio / Original / Patients / Prognosis / Proportional Hazards Models / Proteins / Retrospective Studies / Risk factors / Statistical analysis / Survival / Survival Rate / Tumors