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Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer

by Mehra, Nikita , Al Kamaly, Omkulthom , Mangla, Bharti , Ali, Asgar , Ralli, Tanya , Gupta, Priya , Khan, Zafar , Nasr, Fahd A. , Neupane, Yub Raj , Saleh, Asmaa , Alhalmi, Abdulsalam , Tyagi, Neha , Kohli, Kanchan

in Albumin / Animals / Bioavailability / Biocompatibility / Breast cancer / Cancer / Cancer therapies / Care and treatment / Chemotherapy / Drug approval / Drug Carriers / Drug delivery systems / Drug therapy / Drugs / Estrogens / Fulvestrant / Green chemistry / Green technology / Humans / Iron / Magnetic fields / Magnetic Iron Oxide Nanoparticles / Magnetite Nanoparticles - chemistry / Magnetization / MCF-7 Cells / Medical research / Nanoparticles / Nanoparticles - chemistry / Neoplasms / Oxides / Particle size / Polyethylene glycol / Polymers / Rats / serum albumin / SPIONs / superparamagnetic iron-oxide nanoparticles / tamoxifen / Vehicles

2023

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Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer

2023

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Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer

2023

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Journal Article

Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer

Mehra, Nikita,

Al Kamaly, Omkulthom,

Mangla, Bharti,

Ali, Asgar,

Ralli, Tanya,

Gupta, Priya,

Khan, Zafar,

Nasr, Fahd A.,

Neupane, Yub Raj,

Saleh, Asmaa,

Alhalmi, Abdulsalam,

Tyagi, Neha,

Kohli, Kanchan

2023

Overview

In the emerging field of nanomedicine, nanoparticles have been widely considered as drug carriers and are now used in various clinically approved products. Therefore, in this study, we synthesized superparamagnetic iron-oxide nanoparticles (SPIONs) via green chemistry, and the SPIONs were further coated with tamoxifen-conjugated bovine serum albumin (BSA-SPIONs-TMX). The BSA-SPIONs-TMX were within the nanometric hydrodynamic size (117 ± 4 nm), with a small poly dispersity index (0.28 ± 0.02) and zeta potential of −30.2 ± 0.09 mV. FTIR, DSC, X-RD, and elemental analysis confirmed that BSA-SPIONs-TMX were successfully prepared. The saturation magnetization (Ms) of BSA-SPIONs-TMX was found to be ~8.31 emu/g, indicating that BSA-SPIONs-TMX possess superparamagnetic properties for theragnostic applications. In addition, BSA-SPIONs-TMX were efficiently internalized into breast cancer cell lines (MCF-7 and T47D) and were effective in reducing cell proliferation of breast cancer cells, with IC50 values of 4.97 ± 0.42 μM and 6.29 ± 0.21 μM in MCF-7 and T47D cells, respectively. Furthermore, an acute toxicity study on rats confirmed that these BSA-SPIONs-TMX are safe for use in drug delivery systems. In conclusion, green synthesized superparamagnetic iron-oxide nanoparticles have the potential to be used as drug delivery carriers and may also have diagnostic applications.

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Publisher

MDPI AG,MDPI

Subject

/ Animals

/ Cancer