Journal Article

Progress in the development of stabilization strategies for nanocrystal preparations

Li, Jingru, Zhang, Hui, Zheng, Aiping, Gao, Jing, Wang, Zengming

2021

Overview

In recent years, nanocrystal technology has been extensively investigated. Due to the submicron particle size and unique physicochemical properties of nanocrystals, they overcome the problems of low drug solubility and poor bioavailability. Although the structures of nanocrystals are simple, the further development of these materials is hindered by their stability. Drug nanocrystals with particle sizes of 1∼1000 nm usually require the addition of stabilizers such as polymers or surfactants to enhance their stability. The stability of nanocrystal suspensions and the redispersibility of solid nanocrystal drugs are the key factors for the large-scale production of nanocrystal preparations. In this paper, the factors that affect the stability of drug nanocrystal preparations are discussed, and related methods for solving the stability problem are put forward.

• Publisher: Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group
• Subject: Bioavailability / characterization / Chemistry, Pharmaceutical - methods / Crystallization / Drug delivery systems / Drug Stability / Drugs / Excipients - chemistry / Homogenization / Hydrophobic and Hydrophilic Interactions / Molecular Weight / Nanocrystal / Nanocrystals / Nanoparticles / Nanoparticles - chemistry / Particle Size / Pharmaceutical sciences / Physicochemical properties / Polymers / Polymorphism / R&D / Research & development / Sedimentation & deposition / Sediments / solidification / Solids / Solubility / stability / Surface Properties / Surfactants / Suspensions - chemistry / Toxicology