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The mouse lymph node as an ectopic transplantation site for multiple tissues
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The mouse lymph node as an ectopic transplantation site for multiple tissues
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Journal Article
The mouse lymph node as an ectopic transplantation site for multiple tissues
2012
Overview
Komori
et al
. show that hepatocytes, pancreatic islets and thymocytes flourish in the mouse lymph node, suggesting that lymph nodes could serve as a transplantation site for cell therapies.
Cell-based therapy has been viewed as a promising alternative to organ transplantation, but cell transplantation aimed at organ repair is not always possible. Here we show that the mouse lymph node can support the engraftment and growth of healthy cells from multiple tissues. Direct injection of hepatocytes into a single mouse lymph node generated enough ectopic liver mass to rescue the survival of mice with lethal metabolic disease. Furthermore, thymuses transplanted into single lymph nodes of athymic nude mice generated functional immune systems that were capable of rejecting allogeneic and xenogeneic grafts. Additionally, pancreatic islets injected into the lymph nodes of diabetic mice restored normal glucose control. Collectively, these results suggest the practical approach of targeting lymph nodes to restore, maintain or improve tissue and organ functions.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Diabetes Mellitus, Experimental - therapy
/ Fundamental and applied biological sciences. Psychology
/ Green Fluorescent Proteins - metabolism
/ Health. Pharmaceutical industry
/ Hepatocytes - transplantation
/ Industrial applications and implications. Economical aspects
/ Islets of Langerhans - physiology
/ Islets of Langerhans Transplantation
/ Mice
/ Rodents
/ Thymus Gland - transplantation
/ Tissues
