Asset Details
Do you wish to reserve the book?
BK channels play a counter-adaptive role in drug tolerance and dependence
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
BK channels play a counter-adaptive role in drug tolerance and dependence
Do you wish to request the book?
BK channels play a counter-adaptive role in drug tolerance and dependence
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
BK channels play a counter-adaptive role in drug tolerance and dependence
2010
Overview
Disturbance of neural activity by sedative drugs has been proposed to trigger a homeostatic response that resists unfavorable changes in net cellular excitability, leading to tolerance and dependence. The Drosophila slo gene encodes a BK-type Ca²⁺-activated K⁺ channel implicated in functional tolerance to alcohol and volatile anesthetics. We hypothesized that increased expression of BK channels induced by these drugs constitutes the homeostatic adaptation conferring resistance to sedative drugs. In contrast to the dogmatic view that BK channels act as neural depressants, we show that drug-induced slo expression enhances excitability by reducing the neuronal refractory period. Although this neuroadaptation directly counters some effects of anesthetics, it also causes long-lasting enhancement of seizure susceptibility, a common symptom of drug withdrawal. These data provide a possible mechanism for the long-standing counter-adaptive theory for drug tolerance in which homeostatic adaptations triggered by drug exposure to produce drug tolerance become counter-adaptive after drug clearance and result in symptoms of dependence.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Alcohols
/ Animals
/ Drosophila melanogaster - metabolism
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Drugs
/ Ethanol
/ Genes
/ Large conductance calcium activated potassium channels
/ Large-Conductance Calcium-Activated Potassium Channels - genetics
/ Large-Conductance Calcium-Activated Potassium Channels - metabolism
/ Neurons
/ Potassium channels (calcium-gated)
/ Seizures
/ Substance-Related Disorders - genetics
/ Substance-Related Disorders - metabolism
/ Vapors
