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TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

by Zygmunt, Peter M. , Laavola, Mirka , Moilanen, Lauri J. , Högestätt, Edward D. , Korhonen, Riku , Kukkonen, Meiju , Leppänen, Tiina , Nieminen, Riina M. , Moilanen, Eeva

in 631/154/555 / 631/250/2502 / 631/378/2586 / 692/700/139/422 / Acetanilides - pharmacology / Animals / Basic Medicine / Carrageenan - toxicity / Edema - chemically induced / Edema - prevention & control / Farmakologi och toxikologi / HEK293 Cells / Humanities and Social Sciences / Humans / Ibuprofen - pharmacology / Läkemedelskemi / Medical and Health Sciences / Medicin och hälsovetenskap / Medicinal Chemistry / Medicinska och farmaceutiska grundvetenskaper / Mice / Mice, Inbred C57BL / multidisciplinary / Pharmacology and Toxicology / Purines - pharmacology / Science / Transient Receptor Potential Channels - agonists / Transient Receptor Potential Channels - physiology / TRPA1 Cation Channel

2012

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TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

by Zygmunt, Peter M. , Laavola, Mirka , Moilanen, Lauri J. , Högestätt, Edward D. , Korhonen, Riku , Kukkonen, Meiju , Leppänen, Tiina , Nieminen, Riina M. , Moilanen, Eeva

2012

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TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

by Zygmunt, Peter M. , Laavola, Mirka , Moilanen, Lauri J. , Högestätt, Edward D. , Korhonen, Riku , Kukkonen, Meiju , Leppänen, Tiina , Nieminen, Riina M. , Moilanen, Eeva

2012

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Journal Article

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

Zygmunt, Peter M.,

Laavola, Mirka,

Moilanen, Lauri J.,

Högestätt, Edward D.,

Korhonen, Riku,

Kukkonen, Meiju,

Leppänen, Tiina,

Nieminen, Riina M.,

Moilanen, Eeva

2012

Overview

Transient receptor potential ankyrin 1 (TRPA1) is an ion channel involved in thermosensation and nociception. TRPA1 is activated by exogenous irritants and also by oxidants formed in inflammatory reactions. However, our understanding of its role in inflammation is limited. Here, we tested the hypothesis that TRPA1 is involved in acute inflammatory edema. The TRPA1 agonist allyl isothiocyanate (AITC) induced inflammatory edema when injected intraplantarly to mice, mimicking the classical response to carrageenan. Interestingly, the TRPA1 antagonist HC-030031 and the cyclo-oxygenase (COX) inhibitor ibuprofen inhibited not only AITC but also carrageenan-induced edema. TRPA1-deficient mice displayed attenuated responses to carrageenan and AITC. Furthermore, AITC enhanced COX-2 expression in HEK293 cells transfected with human TRPA1, a response that was reversed by HC-030031. This study demonstrates a hitherto unknown role of TRPA1 in carrageenan-induced inflammatory edema. The results also strongly suggest that TRPA1 contributes, in a COX-dependent manner, to the development of acute inflammation.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ Acetanilides - pharmacology

/ Animals

/ Basic Medicine