Journal Article

Identification of Key Influencers for Secondary Distribution of HIV Self-Testing Kits Among Chinese Men Who Have Sex With Men: Development of an Ensemble Machine Learning Approach

Ye, Yang, Cheng, Weibin, He, Xi, Ong, Jason, Xu, Chen, Dai, Wencan, Tang, Weiming, Ni, Yuxin, Tucker, Joseph D, Yan, Xumeng, Mei, Wenhua, Lu, Ying, Huang, Liqun, Jing, Fengshi, Zhang, Qingpeng, Li, Xiaofeng, Zhou, Yi, Wang, Cheng, Xiong, Yuan, Huang, Shanzi, Wu, Dan, Jiang, Hongbo

2023

Overview

HIV self-testing (HIVST) has been rapidly scaled up and additional strategies further expand testing uptake. Secondary distribution involves people (defined as \"indexes\") applying for multiple kits and subsequently sharing them with people (defined as \"alters\") in their social networks. However, identifying key influencers is difficult. This study aimed to develop an innovative ensemble machine learning approach to identify key influencers among Chinese men who have sex with men (MSM) for secondary distribution of HIVST kits. We defined three types of key influencers: (1) key distributors who can distribute more kits, (2) key promoters who can contribute to finding first-time testing alters, and (3) key detectors who can help to find positive alters. Four machine learning models (logistic regression, support vector machine, decision tree, and random forest) were trained to identify key influencers. An ensemble learning algorithm was adopted to combine these 4 models. For comparison with our machine learning models, self-evaluated leadership scales were used as the human identification approach. Four metrics for performance evaluation, including accuracy, precision, recall, and F -score, were used to evaluate the machine learning models and the human identification approach. Simulation experiments were carried out to validate our approach. We included 309 indexes (our sample size) who were eligible and applied for multiple test kits; they distributed these kits to 269 alters. We compared the performance of the machine learning classification and ensemble learning models with that of the human identification approach based on leadership self-evaluated scales in terms of the 2 nearest cutoffs. Our approach outperformed human identification (based on the cutoff of the self-reported scales), exceeding by an average accuracy of 11.0%, could distribute 18.2% (95% CI 9.9%-26.5%) more kits, and find 13.6% (95% CI 1.9%-25.3%) more first-time testing alters and 12.0% (95% CI -14.7% to 38.7%) more positive-testing alters. Our approach could also increase the simulated intervention's efficiency by 17.7% (95% CI -3.5% to 38.8%) compared to that of human identification. We built machine learning models to identify key influencers among Chinese MSM who were more likely to engage in secondary distribution of HIVST kits. Chinese Clinical Trial Registry (ChiCTR) ChiCTR1900025433; https://www.chictr.org.cn/showproj.html?proj=42001.

• Publisher: Journal of Medical Internet Research,Gunther Eysenbach MD MPH, Associate Professor,JMIR Publications
• Subject: Accuracy / Analysis / Artificial intelligence / Asian cultural groups / Classification / Clinical research / Clinical trials / Decision making / Decision trees / Distribution / East Asian People / Experiments / Gays & lesbians / HIV / HIV (Viruses) / HIV Infections - diagnosis / HIV testing / Homosexuality, Male / Human immunodeficiency virus / Humans / Identification / Identification systems / Incentives / Indexes / Leadership / Machine learning / Male / Medical tests / Men who have sex with men / Mens health / Monetary incentives / Multimedia / Reagent Kits, Diagnostic / Registration / Regression analysis / Self Care / Self evaluation / Self report / Self-Testing / Sexual and Gender Minorities / Simulation / Social networks / Support vector machines / Tests / Uptake / Variables