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Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program
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Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program
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Journal Article
Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program
2017
Overview
Objective
We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.
Methods
The study was conducted in the placebo (
n
= 1082) and intensive lifestyle (
n
= 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (
n
= 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.
Results
In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (
p
< 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.
Conclusion
Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Adult
/ adults
/ Chemistry and Materials Science
/ Diabetes Mellitus, Type 2 - blood
/ Diabetes Mellitus, Type 2 - prevention & control
/ Female
/ Humans
/ Intra-Abdominal Fat - metabolism
/ Male
/ noninsulin-dependent diabetes mellitus
/ placebos
/ Prediabetic State - drug therapy
/ Seasons
/ Subcutaneous Fat, Abdominal - metabolism
