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Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth
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Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth
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Journal Article
Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth
2024
Overview
The proficiency of phyllosphere microbiomes in efficiently utilizing plant-provided nutrients is pivotal for their successful colonization of plants. The methylotrophic capabilities of
Methylobacterium/Methylorubrum
play a crucial role in this process. However, the precise mechanisms facilitating efficient colonization remain elusive. In the present study, we investigate the significance of methanol assimilation in shaping the success of mutualistic relationships between methylotrophs and plants. A set of strains originating from
Methylorubrum extorquens
AM1 are subjected to evolutionary pressures to thrive under low methanol conditions. A mutation in the phosphoribosylpyrophosphate synthetase gene is identified, which converts it into a metabolic valve. This valve redirects limited C1-carbon resources towards the synthesis of biomass by up-regulating a non-essential phosphoketolase pathway. These newly acquired bacterial traits demonstrate superior colonization capabilities, even at low abundance, leading to increased growth of inoculated plants. This function is prevalent in
Methylobacterium
/
Methylorubrum
strains. In summary, our findings offer insights that could guide the selection of
Methylobacterium
/
Methylorubrum
strains for advantageous agricultural applications.
A point mutation in the phosphoribosylpyrophosphate synthetase gene is found to rewire C1 metabolism and thereby enhance colonization capabilities and growth-promoting effects in plants. The effect of this mutation is prevalent across Methylobacterium strains.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/88
/ 45/23
/ 45/29
/ 45/41
/ 82/58
/ 82/80
/ Aldehyde-Lyases - metabolism
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biomass
/ Humanities and Social Sciences
/ Methanol
/ Methylobacterium - enzymology
/ Methylobacterium - growth & development
/ Methylobacterium - metabolism
/ Methylobacterium extorquens - enzymology
/ Methylobacterium extorquens - genetics
/ Methylobacterium extorquens - growth & development
/ Methylobacterium extorquens - metabolism
/ Mutation
/ Plant Leaves - growth & development
/ Science
