Asset Details
Do you wish to reserve the book?
Real-world risk factors for incomplete cytoreduction in peritoneal carcinomatosis patients scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Real-world risk factors for incomplete cytoreduction in peritoneal carcinomatosis patients scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Do you wish to request the book?
Real-world risk factors for incomplete cytoreduction in peritoneal carcinomatosis patients scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Real-world risk factors for incomplete cytoreduction in peritoneal carcinomatosis patients scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
2025
Overview
Background
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for selected patients with peritoneal carcinomatosis. This study investigates preoperative factors influencing incomplete CRS.
Methods
We retrospectively reviewed 188 patients scheduled for curative-intent CRS/HIPEC between April 2015 and May 2023. Preoperative peritoneal cancer index (PCI) scores were determined using computed tomography (CT) (
n
= 155) and/or magnetic resonance imaging (MRI) (
n
= 82).
Results
Complete CRS was achieved in 126 patients (67.0%) and incomplete CRS in 62 (32.9%). Colorectal cancer was the predominant primary tumor (complete CRS: 42.9%; incomplete CRS: 50.0%), followed by ovarian cancer (34.1% vs. 17.7%). Multivariate analysis revealed imaging-specific risk factors: the CT model identified ascites (OR = 4.57) and higher PCI scores in regions 0 and 11, while the MRI model identified prior chemotherapy (OR = 101.06) and higher PCI scores in regions 2, 3, and 11. Decision tree analysis showed ascites altered PCI thresholds for patients with ascites (CT: 18.5, MRI: 6.5) versus without (CT: 8.5, MRI: 12.5). Both imaging modalities demonstrated moderate agreement with surgical findings for total PCI scores (ICC = 0.656 and 0.678), with stronger correlations in regions 0–8 than regions 9–12. Small bowel regions showed poor accuracy, with lowest sensitivity in region 11.
Conclusions
Ascites and higher PCI scores in specific regions identified on preoperative imaging were associated with increased risk of incomplete CRS. These findings can improve patient selection and preoperative planning for CRS/HIPEC in peritoneal carcinomatosis.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Accuracy
/ Adult
/ Aged
/ Analysis
/ Ascites
/ Cancer
/ Colorectal Neoplasms - pathology
/ Colorectal Neoplasms - therapy
/ Computed tomography; magnetic resonance imaging
/ Cytoreduction Surgical Procedures - methods
/ Female
/ Humans
/ Hyperthermic intraperitoneal chemotherapy
/ Hyperthermic Intraperitoneal Chemotherapy - methods
/ Male
/ Medicine
/ Patients
/ Peritoneal Neoplasms - diagnostic imaging
/ Peritoneal Neoplasms - pathology
/ Peritoneal Neoplasms - secondary
/ Peritoneal Neoplasms - therapy
/ Software
/ Surgery
/ Tumors
