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Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
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Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
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Journal Article
Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
2021
Overview
The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carcinoma (HCC). This case–control study aimed to understand the significance of PD-1 polymorphisms (
PD-1.5 and PD-1.9
) association with HBV infection risk and HBV-induced liver disease progression. Genotyping of
PD-1.5
and
PD-1.9
variants was performed by direct Sanger sequencing in 682 HBV-infected patients including chronic hepatitis (CHB, n = 193), liver cirrhosis (LC, n = 183), hepatocellular carcinoma (HCC, n = 306) and 283 healthy controls (HC). To analyze the association of
PD-1
variants with liver disease progression, a binary logistic regression, adjusted for age and gender, was performed using different genetic models. The
PD-1.9 T
allele and
PD-1.9 TT
genotype are significantly associated with increased risk of LC, HCC, and LC + HCC. The frequencies of
PD-1.5 TT
genotype and
PD-1.5 T
allele are significantly higher in HCC compared to LC patients. The haplotype
CT
(
PD-1.5 C
and
PD-1.9 T
) was significantly associated with increased risk of LC, HCC, and LC + HCC. In addition, the
TC
(
PD-1.5 T
and
PD-1.9 C
) haplotype was associated with the risk of HCC compared to non-HCC. The
PD-1.5 CC, PD-1.9 TT,
genotype, and the
CC
(
PD-1.5 C
and
PD-1.9)
haplotype are associated with unfavorable laboratory parameters in chronic hepatitis B patients.
PD-1.5
and
PD1.9
are useful prognostic predictors for HBV infection risk and liver disease progression.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4017
/ Adult
/ Aged
/ Alleles
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - metabolism
/ Female
/ Genetic Predisposition to Disease
/ Hepatitis B, Chronic - genetics
/ Hepatitis B, Chronic - metabolism
/ Humanities and Social Sciences
/ Humans
/ Liver
/ Liver Cirrhosis - metabolism
/ Liver Neoplasms - metabolism
/ Male
/ Programmed Cell Death 1 Receptor - genetics
/ Science
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