Asset Details
Do you wish to reserve the book?
The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia
Do you wish to request the book?
The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia
2016
Overview
Purpose
Corticosteroids can affect sleep patterns, mood, and behavior. Two of the most commonly prescribed corticosteroids in acute lymphoblastic leukemia (ALL), dexamethasone and prednisone, may impact sleep differently, but no research has compared these medications in children. The current study tested the hypothesis that dexamethasone and prednisone differentially affect sleep in children with ALL to understand how these medications contribute to health-related quality of life (HRQL).
Methods
Parents of 81 children 3–12 years old in maintenance therapy for ALL completed a baseline measure of child sleep (dexamethasone
n
= 55, prednisone
n
= 26), and 61 parents returned 28 days of child sleep diaries starting the first day of a 5-day steroid course (dexamethasone
n
= 43, prednisone
n
= 18). Parents also completed measures of HRQL and fatigue on the last day of steroids and the last day of the month.
Results
At baseline, parents reported more sleep disturbances in children taking dexamethasone than prednisone. Across the month, children taking dexamethasone experienced poorer sleep quality compared to children taking prednisone. During corticosteroid treatment, children taking dexamethasone also experienced more night awakenings than children taking prednisone. Sleep variables accounted for almost half of the variance in HRQL during time off steroids and also significantly contributed to fatigue during the corticosteroids course and time off corticosteroids.
Conclusions
Sleep is an essential component of HRQL in children taking corticosteroids, and the impact on sleep is more pronounced in children taking dexamethasone compared to prednisone. Screening for sleep disturbances and offering brief interventions to manage steroid-related sleep disruptions may improve HRQL.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Adrenal Cortex Hormones - therapeutic use
/ Anti-Inflammatory Agents - therapeutic use
/ Child
/ Children
/ Dexamethasone - therapeutic use
/ Diaries
/ Drugs
/ Emotions
/ Fatigue
/ Female
/ Hormones
/ Humans
/ Leukemia
/ Male
/ Medicine
/ Nursing
/ Oncology
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
/ Prednisone - therapeutic use
/ Sleep
/ Sleep Wake Disorders - etiology
/ Steroids
