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Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients
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Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients
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Journal Article
Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients
2012
Overview
Gastric cancer is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. To date, there is a lack of efficient therapeutic protocols for gastric cancer. Recent studies suggest that cancer stem cells （CSCs） are responsible for tumor initiation, invasion, metastasis, and resistance to anticancer therapies. Thus, therapies that target gastric CSCs are attractive. However, CSCs in human gastric adenocarcinoma （GAC） have not been described. Here, we identify CSCs in tumor tissues and peripheral blood from GAC patients. CSCs of human GAC （GCSCs） that are isolated from tumor tissues and peripheral blood of patients carried CD44 and CD54 surface markers, generated tumors that highly resemble the original human tumors when injected into immuno- deficient mice, differentiated into gastric epithelial cells in vitro, and self-renewed in vivo and in vitro. Our findings suggest that effective therapeutic protocols must target GCSCs. The capture of GCSCs from the circulation of GAC patients also shows great potential for identification of a critical cell population potentially responsible for tumor me- tastasis, and provides an effective protocol for early diagnosis and longitudinal monitoring of gastric cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomarkers, Tumor - metabolism
/ Biomedical and Life Sciences
/ Cell Transformation, Neoplastic - metabolism
/ Humans
/ Hyaluronan Receptors - metabolism
/ Intercellular Adhesion Molecule-1 - metabolism
/ Mice
/ Neoplastic Stem Cells - metabolism
/ Neoplastic Stem Cells - pathology
/ Neoplastic Stem Cells - transplantation
/ Original
/ Stomach Neoplasms - pathology
/ Survival
/ Tissues
/ Tumors
/ Xenograft Model Antitumor Assays
/ 外周血
/ 干细胞
/ 患者
/ 癌症
/ 肿瘤组织
/ 胃癌
/ 腺癌
/ 识别
