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Expression and prognostic analyses of ITGA11 , ITGB4 and ITGB8 in human non-small cell lung cancer
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Expression and prognostic analyses of ITGA11 , ITGB4 and ITGB8 in human non-small cell lung cancer
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Journal Article
Expression and prognostic analyses of ITGA11 , ITGB4 and ITGB8 in human non-small cell lung cancer
2019
Overview
Integrins play a crucial role in the regulation process of cell proliferation, migration, differentiation, tumor invasion and metastasis.
,
and
are three encoding genes of integrins family. Accumulative evidences have proved that abnormal expression of
,
and
are a common phenomenon in different malignances. However, their expression patterns and prognostic roles for patients with non-small cell lung cancer (NSCLC) have not been completely illustrated.
We investigated the expression patterns and prognostic values of
,
and
in patients with NSCLC through using a series of databases and various datasets, including ONCOMINE, GEPIA, HPA, TCGA and GEO datasets.
We found that the expression levels of
and
were significantly upregulated in both LUAD and LUSC, while
was obviously upregulated in LUSC. Additionally, higher expression level of
revealed a worse OS in LUAD.
Our findings suggested that
and
might have the potential ability to act as diagnostic biomarkers for both LUAD and LUSC, while
might serve as diagnostic biomarker for LUSC. Furthermore,
could serve as a potential prognostic biomarker for LUAD.
