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Primary oligodendrocyte death does not elicit anti-CNS immunity
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Journal Article
Primary oligodendrocyte death does not elicit anti-CNS immunity
2012
Overview
The death of oligodendrocytes has been hypothesized to trigger the anti-myelin immunity observed in multiple sclerosis. In a mouse model, the authors show that diffuse oligodendrocyte death alone or in conjunction with immune activation does not initiate any anti-CNS immunity.
Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes. To specifically test such oligodendrocyte death as a trigger for anti-CNS immunity, we inducibly killed oligodendrocytes in an
in vivo
mouse model. Strong microglia-macrophage activation followed oligodendrocyte death, and myelin components in draining lymph nodes made CNS antigens available to lymphocytes. However, even conditions favoring autoimmunity—bystander activation, removal of regulatory T cells, presence of myelin-reactive T cells and application of demyelinating antibodies—did not result in the development of CNS inflammation after oligodendrocyte death. In addition, this lack of reactivity was not mediated by enhanced myelin-specific tolerance. Thus, in contrast with previously reported impairments of oligodendrocyte physiology, diffuse oligodendrocyte death alone or in conjunction with immune activation does not trigger anti-CNS immunity.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Encephalomyelitis, Autoimmune, Experimental - immunology
/ Encephalomyelitis, Autoimmune, Experimental - pathology
/ Immunity
/ Mice
/ Multiple Sclerosis - immunology
/ Multiple Sclerosis - pathology
