Journal Article

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Muñoz Maniega, Susana, John, Sally, Bell, Steven, Corley, Janie, Deary, Ian J., Pattie, Alison, Harris, Sarah E., Bronson, Paola G., Starr, John M., Valdés Hernández, Maria, Bastin, Mark E., Cox, Simon R., Morris, Zoe, Butterworth, Adam S., Tucker-Drob, Elliot M., Wardlaw, Joanna M., Prins, Bram P., Marioni, Riccardo E.

2020

Overview

Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases. Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/337/475 / 631/378 / 631/378/2612 / 692/4017 / 82/47 / 82/79 / 82/80 / Age / Aged / Aged, 80 and over / Aging / Biomarkers / Biomarkers - blood / Biomarkers - metabolism / Brain / Brain - diagnostic imaging / Brain - metabolism / Brain - pathology / Cognition - physiology / Cognitive ability / Female / Humanities and Social Sciences / Humans / Magnetic resonance imaging / Male / multidisciplinary / Nerve Tissue Proteins - blood / Nerve Tissue Proteins - metabolism / Neurology / Plasma levels / Proteins / Proteomics / Science / Science (multidisciplinary) / Substrates