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Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis
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Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis
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Journal Article
Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis
2024
Overview
Plantar fasciitis is the most common cause of heel pain in adults with an overall prevalence of 0.85% in the adult population of the US, affecting over 2 million adults annually. Most current treatment modalities are not supported by sufficient evidence to recommend one particular strategy over another. Topical application of analgesics for soft tissue pain is well established, however the plantar fascia presents challenges in this regard due to thick skin, fibrotic tissue, and an often thickened fat pad. Sixty-two patients with plantar fasciitis were randomized to a placebo controlled trial testing the efficacy of a topical solution of plant terpenes containing camphor, menthol, eugenol, eucalyptol, and vanillin. Skin permeation of the mixture was enhanced with 15% dimethylsulfoxide (DMSO), 1% limonene, and rosemary oil. One ml of solution was applied topically twice daily, and pain scores evaluated on Day 0, Day 1, Day 3, and Day 10. Using the validated foot function index 78.1% of patients reported an 85% or greater decrease in their total pain score by day 10 while placebo treatment was without effect (One Way ANOVA, P < 0.01). This study adapts the treatment modality of topical analgesia for soft tissue pain to a problematic area of the body and shows therapeutic promise.
ClinicalTrials.gov Identifier: NCT05467631
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/699
/ Adult
/ Aged
/ Benzaldehydes - administration & dosage
/ Benzaldehydes - therapeutic use
/ Camphor
/ Camphor - administration & dosage
/ Dimethyl Sulfoxide - administration & dosage
/ Dimethyl Sulfoxide - chemistry
/ Dimethyl Sulfoxide - therapeutic use
/ Eugenol - administration & dosage
/ Fascia
/ Fasciitis, Plantar - drug therapy
/ Female
/ Humanities and Social Sciences
/ Humans
/ Limonene
/ Male
/ Menthol
/ Menthol - administration & dosage
/ NCT
/ Pain
/ Placebos
/ Science
/ Vanillin
