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Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma
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Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma
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Journal Article
Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma
2024
Overview
Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera
Akkermansia
(p < 0.001),
Bacteroides
(p = 0.018), and
Ruminococcus
(p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of
Akkermansia
and
Bacteroides
, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
