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Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
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Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
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Journal Article
Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
2024
Overview
Fibroblast Growth Factors (FGFs) and their cognate receptors, FGFRs, play pivotal roles in a plethora of biological processes, including cell proliferation, differentiation, tissue repair, and metabolic homeostasis. This review provides a comprehensive overview of FGF-FGFR signaling pathways while highlighting their complex regulatory mechanisms and interconnections with other signaling networks. Further, we briefly discuss the FGFs involvement in developmental, metabolic, and housekeeping functions. By complementing current knowledge and emerging research, this review aims to enhance the understanding of FGF-FGFR-mediated signaling and its implications for health and disease, which will be crucial for therapeutic development against FGF-related pathological conditions.
Publisher
MDPI AG,MDPI
