Asset Details
Do you wish to reserve the book?
p53 mutations in cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
p53 mutations in cancer
Do you wish to request the book?
p53 mutations in cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
p53 mutations in cancer
2013
Overview
Muller and Vousden discuss the functional outcomes of mutant p53 in cancer and outline the mechanisms through which gain-of-function mutant p53 forms exert their oncogenic effects.
In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/67
/ Animals
/ Biology
/ Cancer
/ Gene Expression Regulation, Neoplastic
/ Humans
/ Mutant Proteins - metabolism
/ Mutant Proteins - physiology
/ Mutants
/ Mutation
/ Protein Processing, Post-Translational
/ Proteins
/ Transcription Factors - metabolism
/ Transcription Factors - physiology
/ Tumor Suppressor Protein p53 - genetics
/ Tumor Suppressor Protein p53 - metabolism
/ Tumor Suppressor Protein p53 - physiology
/ Tumor Suppressor Proteins - metabolism
/ Tumor Suppressor Proteins - physiology
/ Tumors
