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Distinct descending motor cortex pathways and their roles in movement
by
Looger, Loren L
, Graybuck, Lucas T
, Chandrashekar, Jayaram
, Nguyen, Thuc Nghi
, Gerfen, Charles R
, Zeng, Hongkui
, Tasic, Bosiljka
, Bas, Erhan
, Yao, Zizhen
, Economo, Michael N
, Smith, Kimberly A
, Svoboda, Karel
, Wang, Lihua
, Winnubst, Johan
, Viswanathan, Sarada
, Menon, Vilas
in
Analysis
/ Animals
/ Basal ganglia
/ Basal Ganglia - cytology
/ Bioinformatics
/ Brain
/ Brain research
/ Brain stem
/ Brain Stem - cytology
/ Cortex (motor)
/ Criminal investigation
/ Efferent Pathways - cytology
/ Efferent Pathways - physiology
/ Ganglia
/ Gene expression
/ Glutamic Acid - metabolism
/ Health aspects
/ Human mechanics
/ Medulla oblongata
/ Medulla Oblongata - cytology
/ Mice
/ Motor cortex
/ Motor Cortex - cytology
/ Motor Cortex - physiology
/ Motor task performance
/ Motors
/ Movement - physiology
/ Neurons
/ Neurons - metabolism
/ Neurophysiology
/ Pyramidal cells
/ Pyramidal Cells - classification
/ Pyramidal Cells - physiology
/ Single-Cell Analysis
/ Taxonomy
/ Thalamus
/ Transcription
/ Transcriptome
2018
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Distinct descending motor cortex pathways and their roles in movement
by
Looger, Loren L
, Graybuck, Lucas T
, Chandrashekar, Jayaram
, Nguyen, Thuc Nghi
, Gerfen, Charles R
, Zeng, Hongkui
, Tasic, Bosiljka
, Bas, Erhan
, Yao, Zizhen
, Economo, Michael N
, Smith, Kimberly A
, Svoboda, Karel
, Wang, Lihua
, Winnubst, Johan
, Viswanathan, Sarada
, Menon, Vilas
in
Analysis
/ Animals
/ Basal ganglia
/ Basal Ganglia - cytology
/ Bioinformatics
/ Brain
/ Brain research
/ Brain stem
/ Brain Stem - cytology
/ Cortex (motor)
/ Criminal investigation
/ Efferent Pathways - cytology
/ Efferent Pathways - physiology
/ Ganglia
/ Gene expression
/ Glutamic Acid - metabolism
/ Health aspects
/ Human mechanics
/ Medulla oblongata
/ Medulla Oblongata - cytology
/ Mice
/ Motor cortex
/ Motor Cortex - cytology
/ Motor Cortex - physiology
/ Motor task performance
/ Motors
/ Movement - physiology
/ Neurons
/ Neurons - metabolism
/ Neurophysiology
/ Pyramidal cells
/ Pyramidal Cells - classification
/ Pyramidal Cells - physiology
/ Single-Cell Analysis
/ Taxonomy
/ Thalamus
/ Transcription
/ Transcriptome
2018
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Distinct descending motor cortex pathways and their roles in movement
by
Looger, Loren L
, Graybuck, Lucas T
, Chandrashekar, Jayaram
, Nguyen, Thuc Nghi
, Gerfen, Charles R
, Zeng, Hongkui
, Tasic, Bosiljka
, Bas, Erhan
, Yao, Zizhen
, Economo, Michael N
, Smith, Kimberly A
, Svoboda, Karel
, Wang, Lihua
, Winnubst, Johan
, Viswanathan, Sarada
, Menon, Vilas
in
Analysis
/ Animals
/ Basal ganglia
/ Basal Ganglia - cytology
/ Bioinformatics
/ Brain
/ Brain research
/ Brain stem
/ Brain Stem - cytology
/ Cortex (motor)
/ Criminal investigation
/ Efferent Pathways - cytology
/ Efferent Pathways - physiology
/ Ganglia
/ Gene expression
/ Glutamic Acid - metabolism
/ Health aspects
/ Human mechanics
/ Medulla oblongata
/ Medulla Oblongata - cytology
/ Mice
/ Motor cortex
/ Motor Cortex - cytology
/ Motor Cortex - physiology
/ Motor task performance
/ Motors
/ Movement - physiology
/ Neurons
/ Neurons - metabolism
/ Neurophysiology
/ Pyramidal cells
/ Pyramidal Cells - classification
/ Pyramidal Cells - physiology
/ Single-Cell Analysis
/ Taxonomy
/ Thalamus
/ Transcription
/ Transcriptome
2018
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Distinct descending motor cortex pathways and their roles in movement
Journal Article
Distinct descending motor cortex pathways and their roles in movement
2018
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Overview
Activity in the motor cortex predicts movements, seconds before they are initiated. This preparatory activity has been observed across cortical layers, including in descending pyramidal tract neurons in layer 5. A key question is how preparatory activity is maintained without causing movement, and is ultimately converted to a motor command to trigger appropriate movements. Here, using single-cell transcriptional profiling and axonal reconstructions, we identify two types of pyramidal tract neuron. Both types project to several targets in the basal ganglia and brainstem. One type projects to thalamic regions that connect back to motor cortex; populations of these neurons produced early preparatory activity that persisted until the movement was initiated. The second type projects to motor centres in the medulla and mainly produced late preparatory activity and motor commands. These results indicate that two types of motor cortex output neurons have specialized roles in motor control.
Publisher
Nature Publishing Group
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