Asset Details
Do you wish to reserve the book?
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
Do you wish to request the book?
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
2024
Overview
Summary
Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose a growing global health threat due to the rise of drug-resistant strains. New therapeutic strategies are urgently needed to combat this challenge. The PCA pathway for biosynthesis of Co-enzyme A (CoA) and Acetyl-CoA (AcCoA) from vitamin B5 (pantothenic acid) has been validated as an excellent target for the development of new antimicrobials against fungi and protozoa. The pathway regulates key cellular processes including metabolism of fatty acids, amino acids, sterols, and heme. In this study, we provide genetic evidence that disruption of the PCA pathway in
Saccharomyces cerevisiae
results in a significant alteration in the susceptibility of fungi to a wide range of xenobiotics, including clinically approved antifungal drugs through alteration of vacuolar morphology and drug detoxification. The drug potentiation mediated by genetic regulation of genes in the PCA pathway could be recapitulated using the pantazine analog PZ-2891 as well as the celecoxib derivative, AR-12 through inhibition of fungal AcCoA synthase activity. Collectively, the data validate the PCA pathway as a suitable target for enhancing the efficacy and safety of current antifungal therapies.
The PCA pathway, essential for synthesizing CoA and AcCoA from vitamin B5, plays a crucial role in fungal cellular processes. Targeting this pathway could enhance antifungal drug efficacy by affecting vacuolar morphology and drug detoxification.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/1
/ 14/28
/ 14/34
/ 14/63
/ 38/22
/ 38/39
/ 45/90
/ Antifungal Agents - metabolism
/ Antifungal Agents - pharmacology
/ Biomedical and Life Sciences
/ Drug Resistance, Fungal - genetics
/ Fungi
/ Pantothenic Acid - metabolism
/ Saccharomyces cerevisiae - drug effects
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - metabolism
/ Sterols
