Asset Details
Do you wish to reserve the book?
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
Do you wish to request the book?
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
2020
Overview
Brown adipose tissue generates heat via the mitochondrial uncoupling protein UCP1 to protect against obesity and hypothermia.
Fas
mutant MRL/lpr mice exhibit a significantly leaner phenotype compared to wild type MRL/MpJ mice. In this study, we evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. Furthermore, we compared beige fat activity between the MRL/MpJ and MRL/lpr mice.
Fas
mutation resulted in high body temperature, improved glucose tolerance, and decreased fat mass and adipocyte size.
Fas
mutation prevented high-fat diet-induced obesity and decreased the white adipose tissue M1:M2 ratio. When mice were fed a high-fat diet,
UCP1
,
IL-4
,
IL-10
, and tyrosine hydroxylase genes had significantly higher expression in
Fas
-mutant mice than in wild type mice. After a cold challenge, UCP1 expression and browning were also significantly higher in the
Fas
-mutant mice. In summary,
Fas
-mutant mice are resistant to high-fat diet-induced obesity due to increased IL-4 and IL-10 levels and the promotion of thermogenic protein activity and browning in their adipose tissues. STAT6 activation might contribute to M2 polarisation by increasing IL-4 and IL-10 levels while increases in M2 and tyrosine hydroxylase levels promote browning in response to
Fas
mutation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
