Asset Details
Do you wish to reserve the book?
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation
Do you wish to request the book?
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation
2016
Overview
Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo–uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown. Here we provide evidence that planar cell polarity (PCP) signaling orchestrates directed epithelial evaginations to form crypts for implantation in mice. Uterine deletion of Vang-like protein 2, but not Vang-like protein 1, conferred aberrant PCP signaling, misdirected epithelial evaginations, defective crypt formation, and blastocyst attachment, leading to severely compromised pregnancy outcomes. The study reveals a previously unrecognized role for PCP in executing spatial cues for crypt formation and implantation. Because PCP is an evolutionarily conserved phenomenon, our study is likely to inspire implantation studies of this signaling pathway in humans and other species.
Publisher
National Academy of Sciences
Subject
/ Bone Morphogenetic Protein 2 - genetics
/ Bone Morphogenetic Protein 2 - physiology
/ Carrier Proteins - physiology
/ Cell Communication - physiology
/ Dishevelled Proteins - physiology
/ Embryo Implantation - physiology
/ Embryos
/ Epithelium - anatomy & histology
/ Female
/ Male
/ Mice
/ Nerve Tissue Proteins - deficiency
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - physiology
/ Proteins
/ Receptor Tyrosine Kinase-like Orphan Receptors - deficiency
/ Receptor Tyrosine Kinase-like Orphan Receptors - genetics
/ Receptor Tyrosine Kinase-like Orphan Receptors - physiology
/ Signal Transduction - physiology
