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The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
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The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
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Journal Article
The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
2016
Overview
The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga,
Gonium pectorale,
where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the
Gonium
retinoblastoma cell cycle regulator in unicellular
Chlamydomonas
causes it to become colonial. The presence of these changes in undifferentiated
Gonium
indicates extensive group-level adaptation during the initial step in the evolution of multicellularity. These results emphasize an early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation, one that may shed light on the evolutionary history of other multicellular innovations and evolutionary transitions.
The undifferentiated
Gonium pectorale
represents the initial transition to multicellularity. Here, Bradley Olson, Erik Hanschen and colleagues describe the genome of
Gonium pectorale
, demonstrating that co-option of the retinoblastoma cell cycle regulatory pathway was a key genetic change in the evolution of multicellularity.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
