Asset Details
Do you wish to reserve the book?
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
Do you wish to request the book?
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
2025
Overview
Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic. In this work, we demonstrate that a subset of sustentacular cells endowed with a support role, are in fact adrenomedullary stem cells. Through genetic tracing and comprehensive transcriptomic data of the mouse adrenal medulla, we show that cells expressing
Sox2/
SOX2 specialise as a unique postnatal population from embryonic Schwann Cell Precursors and are also present in the normal adult human adrenal medulla. Postnatal SOX2
+
cells give rise to chromaffin cells of both the adrenaline and noradrenaline lineages in vivo and in vitro. We reveal that SOX2
+
stem cells have a second, paracrine role in maintaining adrenal chromaffin cell homeostasis, where they promote proliferation through paracrine secretion of WNT6. This work identifies SOX2
+
cells as a true stem cell for catecholamine-secreting chromaffin cells.
The adrenal medulla secretes hormones required for the fight-or-flight response, and its specialized cells need to be maintained throughout life. This study uses mouse models to pinpoint the stem cells of this organ and demonstrates how these ensure the turnover of specialized cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 38
/ 38/1
/ 38/32
/ 38/39
/ 45
/ 45/100
/ 45/91
/ 64/110
/ 64/60
/ Adrenal Medulla - metabolism
/ Animals
/ Chromaffin Cells - metabolism
/ Female
/ Hormones
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mice
/ Science
/ SOXB1 Transcription Factors - genetics
