Asset Details
Do you wish to reserve the book?
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Do you wish to request the book?
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
2021
Overview
Abstract
Context
Estradiol is the primary female sex hormone and plays an important role for skeletal health in both sexes. Several enzymes are involved in estradiol metabolism, but few genome-wide association studies (GWAS) have been performed to characterize the genetic contribution to variation in estrogen levels.
Objective
Identify genetic loci affecting estradiol levels and estimate causal effect of estradiol on bone mineral density (BMD).
Design
We performed GWAS for estradiol in males (n = 147 690) and females (n = 163 985) from UK Biobank. Estradiol was analyzed as a binary phenotype above/below detection limit (175 pmol/L). We further estimated the causal effect of estradiol on BMD using Mendelian randomization.
Results
We identified 14 independent loci associated (P < 5 × 10−8) with estradiol levels in males, of which 1 (CYP3A7) was genome-wide and 7 nominally (P < 0.05) significant in females. In addition, 1 female-specific locus was identified. Most loci contain functionally relevant genes that have not been discussed in relation to estradiol levels in previous GWAS (eg, SRD5A2, which encodes a steroid 5-alpha reductase that is involved in processing androgens, and UGT3A1 and UGT2B7, which encode enzymes likely to be involved in estradiol elimination). The allele that tags the O blood group at the ABO locus was associated with higher estradiol levels. We identified a causal effect of high estradiol levels on increased BMD in both males (P = 1.58 × 10−11) and females (P = 7.48 × 10−6).
Conclusion
Our findings further support the importance of the body’s own estrogen to maintain skeletal health in males and in females.
Publisher
Oxford University Press
Subject
/ 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics
/ ABO Blood-Group System - genetics
/ Analysis
/ Bones
/ Cytochrome P-450 CYP3A - genetics
/ Density
/ Enzymes
/ Estrogen
/ Female
/ Females
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Genomics
/ Genotype
/ Glucuronosyltransferase - genetics
/ GWAS
/ Humans
/ Male
/ Males
/ Membrane Proteins - genetics
/ Mendelian Randomization Analysis
/ N-Acetylglucosaminyltransferases - genetics
/ Phenols
