Journal Article

Fungal L-Methionine Biosynthesis Pathway Enzymes and Their Applications in Various Scientific and Commercial Fields

Rząd, Kamila, Gabriel, Iwona, Kuplińska, Aleksandra

2024

Overview

L-methionine (L-Met) is one of the nine proteinogenic amino acids essential for humans since, in human cells, there are no complete pathways for its biosynthesis from simple precursors. L-Met plays a crucial role in cellular function as it is required for proper protein synthesis, acting as an initiator. Additionally, this amino acid participates in various metabolic processes and serves as a precursor for the synthesis of S-adenosylmethionine (AdoMet), which is involved in the methylation of DNA molecules and phospholipids, as well as in maintaining genome stability. Due to its importance, fungal L-methionine biosynthesis pathway enzymes are being intensively studied. This review presents the current state of the art in terms of their cellular function, usefulness as molecular markers, antifungal targets, or industrial approaches.

• Publisher: MDPI AG,MDPI
• Subject: Amino acids / antifungal / Antifungal agents / Biosynthesis / Biosynthetic Pathways / Comparative analysis / Composition / DNA biosynthesis / DNA methylation / Enzymes / Fungal Proteins - genetics / Fungal Proteins - metabolism / Fungi / Fungi - enzymology / Fungi - genetics / Fungi - metabolism / Homocysteine / Humans / Hydrogen sulfide / Identification and classification / L-methionine biosynthesis / L-methionine production / Metabolites / Methionine / Methionine - biosynthesis / Methionine - metabolism / molecular markers / Phospholipids / Physiological aspects / Production processes / Protein biosynthesis / Review / S-Adenosylmethionine / S-Adenosylmethionine - metabolism / Sulfur / wine industry / Yeast