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Intrinsically regulated learning is modulated by synaptic dopamine signaling
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Intrinsically regulated learning is modulated by synaptic dopamine signaling
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Journal Article
Intrinsically regulated learning is modulated by synaptic dopamine signaling
2018
Overview
We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.
Publisher
eLife Sciences Publications Ltd,eLife Sciences,eLife Sciences Publications, Ltd
Subject
/ Cellular signal transduction
/ Dopamine
/ Dopamine Agents - pharmacology
/ Dopamine Antagonists - pharmacology
/ Female
/ Humans
/ language
/ Learning
/ Male
/ Memory
/ Memory, Long-Term - drug effects
/ Memory, Long-Term - physiology
/ Neurons
/ Reward
/ Signal Transduction - drug effects
/ Signal Transduction - physiology
/ Synaptic Transmission - physiology
