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Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)
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Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)
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Journal Article
Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)
1993
Overview
The Lennox-Gastaut syndrome is a severe epileptic encephalopathy that affects children and constitutes approximately 5 percent of childhood epilepsies
1
. The syndrome is characterized by the onset of multiple types of seizures during childhood, including atypical absence and atonic seizures; slow spike-wave electroencephalographic patterns; and mental retardation that is frequently progressive
2
. It is difficult to control the seizures in these patients, even with multiple anticonvulsant drugs,
3
and the prognosis for cognitive development is poor.
Valproate, benzodiazepines, and other antiepileptic drugs are of some benefit in patients with the Lennox-Gastaut syndrome
4
–
6
. The control of seizures sometimes improves when . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Anticonvulsants - administration & dosage
/ Anticonvulsants - adverse effects
/ Anticonvulsants - therapeutic use
/ Anticonvulsants. Antiepileptics. Antiparkinson agents
/ Biological and medical sciences
/ Child
/ Children
/ Dose-Response Relationship, Drug
/ EEG
/ Epilepsy
/ Epilepsy, Generalized - drug therapy
/ Epilepsy, Generalized - physiopathology
/ Female
/ Humans
/ Male
/ Patients
/ Pharmacology. Drug treatments
/ Propylene Glycols - administration & dosage
/ Propylene Glycols - adverse effects
/ Propylene Glycols - therapeutic use
/ Seizures
/ Studies
/ Syndrome
