Journal Article

Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007–2010 to 2017–2018)

Yan, Zhaoqi, Liu, Liangji, Li, Keke, Xu, Yifeng

2023

Overview

Background The association between exposure to environmental metals and chronic obstructive pulmonary disease (COPD) is preventing chronic lung diseases. However, little is currently known about the interaction between heavy metals and flavonoids in relation to the risk of COPD. This study aims to bridge this knowledge gap by leveraging The National Health and Nutrition Examination Survey (NHANES) database to evaluate thecorrelation between blood levels of heavy metals (cadmium, lead, mercury) and the intake of various flavonoid compounds (isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, total flavonoids). Additionally, appropriate dietary recommendations are provided based on the study findings. Materials and methods Cross-sectional analysis was conducted using the 2007–2010 and 2017–2018 NHANES data. Specialized weighted complex survey design analysis software was used for data analysis. Multivariate logistic regression models and restricted cubic splines (RCS) were used to evaluate the relationship between blood heavy metal levels, flavonoids intake, and COPD incidence in all participants, and to explore the effect of different levels of flavonoids intake on COPD caused by heavy metal exposure. Results A total of 7,265 adults aged ≥ 40 years were analyzed. Higher levels of blood cadmium (Cd), blood lead and Anthocyanidin (AC) intake were independently associated with an increased risk of COPD (Cd highest quantile vs. lowest: OR = 1.73, 95% CI, 1.25–2.3; Lead highest quantile vs. lowest quantile: OR = 1.44, 95% CI, 1.11–1.86; AC highest quantile vs. lowest: OR = 0.73, 95% CI, 0.54–0.99). When AC intake exceeded 11.56 mg/d, the effect of Cd exposure on COPD incidence decreased by 27%, and this finding was more significant in smokers. Conclusion Higher levels of Cd (≥ 0.45ug/L) and lead (≥ 0.172 ug/L) were positively correlated with the risk of COPD among participants aged 40 years and above, while AC intake (≥ 11.56 mg/d) could reduce the risk related to blood Cd.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Alcohol / Anthocyanidins / Bioflavonoids / Biostatistics / Blood / Blood levels / Blood pressure / Bronchitis / Cadmium / Cardiovascular disease / Chelating agents / Chronic Obstructive Pulmonary Disease / Cross-Sectional Studies / Data analysis / Design analysis / Diabetes / Diagnosis / Dietary health / Disease control / Disease prevention / Environmental Health / Enzymes / Epidemiology / Exposure / Flavones / Flavonoids / Flavonols / Health aspects / Heart / Heavy metals / Hispanic people / Humans / Hypertension / Isoflavones / Lead / Lung diseases / Lung diseases, Obstructive / Measurement / Medicine / Medicine & Public Health / Mercury / Metal concentrations / Metals, Heavy / Multivariate analysis / Nutrition / Nutrition Surveys / Obstructive lung disease / Oxidative stress / Polyphenols / Prevention / Public Health / Pulmonary Disease, Chronic Obstructive - epidemiology / Quantiles / Questionnaires / Regression analysis / Regression models / Risk / Risk factors / Smoking / Surveys / Toxicity / Vaccine