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Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
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Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
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Journal Article
Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
2020
Overview
Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With
P
= 0.18 (T1D) and
P
= 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00% (± 2.00%) and 15.00% (± 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D (
P
= 1.60 × 10
−24
) and for RA (
P
= 0.02). For the first time, the existence of maternal genetic effects on RA was indicated, contributing up to 16.00% (± 3.00%) of the total variance. Environmental factors such as the social economic index, the number of offspring, birth year as well as their interactions with sex showed large effects.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Arthritis, Rheumatoid - genetics
/ Arthritis, Rheumatoid - pathology
/ Biological Variation, Population
/ Biological Variation, Population - genetics
/ Child
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - genetics
/ Diabetes Mellitus, Type 1 - pathology
/ Epigenesis, Genetic - genetics
/ Female
/ Genetic Predisposition to Disease
/ Genomic Imprinting - genetics
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Imprinting ; Epigenetics ; Population genetics ; Genetics
/ Infant
/ Male
/ Maternal Inheritance - genetics
/ Pedigree
/ Science
