Asset Details
Do you wish to reserve the book?
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis
Do you wish to request the book?
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis
2024
Overview
This study investigated the correlation of Apolipoprotein-B mRNA-editing complex 3B (APOBEC3B) expression with hypoxia inducible factor 1α (HIF-1α), Kirsten rat sarcoma virus (KRAS) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in endometriosis patients, and the inhibitory effects of APOBEC3B knockdown in a human endometriotic cell line. Here, APOBEC3B, HIF-1α, KRAS, and PIK3CA were examined in patients with and without endometriosis using reverse transcription polymerase chain reaction (RT-PCR). The apoptosis, cell proliferation, invasion, migration, and biological function of APOBEC3B knockdown were explored in 12Z immortalized human endometriotic cell line. We observed APOBEC3B, HIF-1α, KRAS and PIK3CA expressions were significantly higher in endometriosis patients (
p
< 0.001,
p
< 0.001,
p
= 0.029,
p
= 0.001). Knockdown of APOBEC3B increased apoptosis, which was 28.03% and 22.27% higher than in mock and control siRNA samples, respectively. APOBEC3B knockdown also decreased PIK3CA expression and increased Caspase 8 expression, suggesting a potential role in the regulation of apoptosis. Furthermore, knockdown of APOBEC3B significantly inhibited cell proliferation, invasion, and migration compared to mock and control siRNA. (Cell proliferation: mock:
p
< 0.001 and control siRNA:
p
= 0.049. Cell invasion: mock:
p
< 0.001 and control siRNA:
p
= 0.029. Cell migration: mock:
p
= 0.004, and control siRNA:
p
= 0.014). In conclusion, this study suggests that APOBEC3B may be a new potential therapeutic target for endometriosis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Apolipoprotein-B mRNA-editing complex 3B
/ Cell Proliferation - genetics
/ Class I Phosphatidylinositol 3-Kinases - genetics
/ Class I Phosphatidylinositol 3-Kinases - metabolism
/ Cytidine Deaminase - genetics
/ Cytidine Deaminase - metabolism
/ Female
/ Humanities and Social Sciences
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit
/ Minor Histocompatibility Antigens - genetics
/ Minor Histocompatibility Antigens - metabolism
/ Phosphatidylinositol 4,5-diphosphate
/ Potential therapeutic target
/ Proto-Oncogene Proteins p21(ras) - genetics
/ Proto-Oncogene Proteins p21(ras) - metabolism
/ Sarcoma
/ Science
/ siRNA
