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Retinoid Signaling Determines Germ Cell Fate in Mice
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Journal Article
Retinoid Signaling Determines Germ Cell Fate in Mice
2006
Overview
Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Cell differentiation, maturation, development, hematopoiesis
/ Cytochrome P-450 Enzyme System - genetics
/ Cytochrome P-450 Enzyme System - metabolism
/ Embryos
/ Enzymes
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Gonads
/ Male
/ Meiosis
/ Mice
/ Molecular and cellular biology
/ oocytes
/ Ovaries
/ Receptors, Retinoic Acid - antagonists & inhibitors
/ Reverse transcriptase polymerase chain reaction
/ Rodents
/ Testes
