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Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite

by Weissman, Drew , Cibichakravarthy, Balasubramanian , Fikrig, Erol , Tang, Xiaotian , Cui, Yingjun , Alameh, Mohamad G. , Dwivedi, Garima

in Acquired tick resistance / Allergy and Immunology / Amino acids / Animals / Antibodies / Arachnids / Coding / Epitopes / Epitopes - immunology / Erythema / Erythema - etiology / Erythema - immunology / Female / Genomes / Guinea / Guinea Pigs / histamine / Immunization / Immunoglobulin G / Immunoglobulin G - blood / Immunoglobulin G - immunology / Infections / Insect bites / Ixodes - immunology / Ixodes scapularis / Laboratory animals / Life sciences / Lipids / Liposomes / mRNA Vaccines / Nanoparticles / Nanoparticles - chemistry / Pathogens / Peptides / Proteins / RNA polymerase / RNA, Messenger - genetics / RNA, Messenger - immunology / Salivary Proteins and Peptides - genetics / Salivary Proteins and Peptides - immunology / Salp14 / Skin / Software / Statistical analysis / Swine / Tick Bites - immunology / Ticks / Transcriptomics / vaccination / Vaccination - methods / Vaccines

2024

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Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite

by Weissman, Drew , Cibichakravarthy, Balasubramanian , Fikrig, Erol , Tang, Xiaotian , Cui, Yingjun , Alameh, Mohamad G. , Dwivedi, Garima

2024

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Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite

by Weissman, Drew , Cibichakravarthy, Balasubramanian , Fikrig, Erol , Tang, Xiaotian , Cui, Yingjun , Alameh, Mohamad G. , Dwivedi, Garima

2024

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Journal Article

Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite

Weissman, Drew,

Cibichakravarthy, Balasubramanian,

Fikrig, Erol,

Tang, Xiaotian,

Cui, Yingjun,

Alameh, Mohamad G.,

Dwivedi, Garima

2024

Overview

Repeated exposure of animals to Ixodes scapularis ticks can result in acquired tick resistance (ATR). The first manifestation of ATR is erythema at the tick bite site, however, the specific peptide targets and mechanisms associated with this early aspect of ATR are not understood. In this study, we immunized guinea pigs with a lipid nanoparticle containing the mRNA encoding 25 amino acids in the carboxyl terminus of Salp14 (Salp14-C mRNA-LNP), an I. scapularis salivary protein. The animals produced high titers of IgG directed at the carboxyl terminus of Salp14. Guinea pigs immunized with Salp14-C mRNA-LNP and then exposed to I. scapularis, developed erythema at the tick bite site. Transcriptomics of the skin of guinea pigs at the I. scapularis bite sites elucidated selected pathways, including histamine activation, that are associated with the development of erythema. The study demonstrates that an mRNA vaccine encoding a small peptide can induce the initial phase of ATR in guinea pigs.

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Publisher

Elsevier Ltd,Elsevier Limited

Subject

Acquired tick resistance

/ Allergy and Immunology

/ Amino acids

/ Animals

/ Antibodies

/ Arachnids

/ Coding