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Serotonin activates dermal papilla cells and promotes hair growth

by Fukuda, Junji , Hamano, Sayuri , Yan, Lei , Seo, Jieun , Kageyama, Tatsuto

in 631/61/2035 / 631/61/490 / Agonists / Alopecia / Animals / Baldness / Dehydrogenases / Dermal papilla cells / Dermis - cytology / Dermis - drug effects / Dermis - metabolism / Follicles / Gene expression / Genomes / Hair / Hair - drug effects / Hair - growth & development / Hair Follicle - cytology / Hair Follicle - drug effects / Hair Follicle - growth & development / Hair Follicle - metabolism / Hair follicle organoid / Hair growth / Homeostasis / Humanities and Social Sciences / Mice / multidisciplinary / Organoids / Organoids - drug effects / Organoids - metabolism / Polymerase chain reaction / Ratios / Science / Science (multidisciplinary) / Serotonin / Serotonin - metabolism / Serotonin - pharmacology / Serotonin Receptor Agonists - pharmacology / Signal Transduction - drug effects / Sumatriptan / Sumatriptan - pharmacology

2025

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Serotonin activates dermal papilla cells and promotes hair growth

by Fukuda, Junji , Hamano, Sayuri , Yan, Lei , Seo, Jieun , Kageyama, Tatsuto

2025

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Serotonin activates dermal papilla cells and promotes hair growth

by Fukuda, Junji , Hamano, Sayuri , Yan, Lei , Seo, Jieun , Kageyama, Tatsuto

2025

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Journal Article

Serotonin activates dermal papilla cells and promotes hair growth

Fukuda, Junji,

Hamano, Sayuri,

Yan, Lei,

Seo, Jieun,

Kageyama, Tatsuto

2025

Overview

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a vital role in regulating behavior, mood, memory, and gastrointestinal homeostasis. Although recent studies have identified an intestine-hair follicle link, potentially implicating 5-HT, its exact relationship with hair growth remains unclear. Here we investigated the effects of serotonin signaling on hair follicle homeostasis. Gene expression analysis showed significant upregulation of hair growth-related genes in dermal papilla cells treated with 5-HT. The hair growth-promoting effects of 5-HT were examined using hair follicle organoids and hair follicle organ cultures. The addition of 5-HT to hair follicle organoids and hair follicles promoted hair shaft elongation. Similar effects were observed with sumatriptan succinate, a 5-HT receptor agonist. These results suggest that targeting serotonin signaling can advance alopecia therapy.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ Animals