Asset Details
Do you wish to reserve the book?
Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
Do you wish to request the book?
Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
2021
Overview
Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 704/172
/ Aged
/ Animals
/ Carcinogens, Environmental - toxicity
/ Carcinoma, Hepatocellular - blood
/ Carcinoma, Hepatocellular - chemically induced
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - pathology
/ Environmental Pollution - analysis
/ Female
/ Humanities and Social Sciences
/ Humans
/ Liver Neoplasms - chemically induced
/ Lymphoma
/ Male
/ Melanoma
/ PCB
/ Polychlorinated Biphenyls - toxicity
/ Rats
/ Science
