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FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
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FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
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Journal Article
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
2011
Overview
Fibroblast growth factor (FGF) 19 is an enterokine synthesized and released when bile acids are taken up into the ileum. We show that FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. Mice lacking FGF15 (the mouse FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial amounts of liver glycogen. FGF19 treatment restored the loss of glycogen in diabetic animals lacking insulin. Thus, FGF19 activates a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ blood
/ Diabetes Mellitus, Experimental - metabolism
/ Eukaryotic Initiation Factors - metabolism
/ Fibroblast Growth Factors - metabolism
/ Fibroblast Growth Factors - pharmacology
/ Fundamental and applied biological sciences. Psychology
/ Glucose
/ Glycogen
/ Glycogen Synthase - metabolism
/ Glycogen Synthase Kinase 3 - metabolism
/ Humans
/ ileum
/ Insulin
/ Kinases
/ Liver
/ Liver Glycogen - biosynthesis
/ Male
/ Metabolisms and neurohumoral controls
/ Mice
/ mitogen-activated protein kinase
/ Pathways
/ Proteins
/ Proto-Oncogene Proteins c-akt - metabolism
/ Ribosomal Protein S6 - metabolism
/ Rodents
/ Vehicles
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
