Journal Article

Distinct abdominal and gluteal adipose tissue transcriptome signatures are altered by exercise training in African women with obesity

Krohn, Knut, Nono Nankam, Pamela A., Kehr, Stephanie, Goedecke, Julia H., Adams, Kevin, Klöting, Nora, Mendham, Amy E., Stadler, Peter F., Blüher, Matthias

2020

Overview

The differential associations of adipose depots with metabolic risk during obesity have been proposed to be controlled by environmental and genetic factors. We evaluated the regional differences in transcriptome signatures between abdominal (aSAT) and gluteal subcutaneous adipose tissue (gSAT) in obese black South African women and tested the hypothesis that 12-week exercise training alters gene expression patterns in a depot-specific manner. Twelve young women performed 12-weeks of supervised aerobic and resistance training. Pre- and post-intervention measurements included peak oxygen consumption (VO 2peak ), whole-body composition and unbiased gene expression analysis of SAT depots. VO 2peak increased, body weight decreased, and body fat distribution improved with exercise training (p < 0.05). The expression of 15 genes, mainly associated with embryonic development, differed between SAT depots at baseline, whereas 318 genes were differentially expressed post-training (p < 0.05). Four developmental genes were differentially expressed between these depots at both time points ( HOXA5, DMRT2 , DMRT3 and CSN1S1 ). Exercise training induced changes in the expression of genes associated with immune and inflammatory responses, and lipid metabolism in gSAT, and muscle-associated processes in aSAT. This study showed differences in developmental processes regulating SAT distribution and expandability of distinct depots, and depot-specific adaptation to exercise training in black South African women with obesity.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/208/199 / 631/443/319/1642/393 / Adipose tissue / Adult / African Continental Ancestry Group - genetics / Body composition / Body fat / Body weight / Buttocks / DNA-Binding Proteins - genetics / Embryogenesis / Embryonic growth stage / Exercise / Exercise Therapy / Female / Fitness training programs / Gene expression / Gene Expression Profiling - methods / Gene Expression Regulation / Gene Regulatory Networks / Genetic factors / Homeodomain Proteins - genetics / Humanities and Social Sciences / Humans / Inflammation / Intra-Abdominal Fat - chemistry / Lipid metabolism / multidisciplinary / Obesity / Obesity - genetics / Obesity - metabolism / Obesity - rehabilitation / Organ Specificity / Oxygen - metabolism / Oxygen consumption / Physical training / Resistance Training / Science / Science (multidisciplinary) / Subcutaneous Fat - chemistry / Transcription Factors - genetics / Young Adult