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Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

by Fu, Guoliang , Huang, Yongping , Tan, Anjiang , Alphey, Luke , Meng, Zhiqi , Morrison, Neil I. , Niu, Baolong , Guo, Qiuhong , Jin, Li , Li, Zhiqian

in alternative splicing / Alternative Splicing - genetics / Animals / Biological Sciences / Bombyx - genetics / Bombyx - physiology / Bombyx mori / Breeding - methods / Cloning, Molecular / cocoons / DNA Primers - genetics / Female / Female animals / females / food consumption / Genes, Lethal - genetics / Genetics / Immunoblotting / Insect control / Insect genetics / Insect larvae / Insect vectors / larvae / Larval development / Male / males / Medical genetics / Microscopy, Fluorescence / Pest control / Pest Control, Biological - methods / Public health / rearing / Reverse Transcriptase Polymerase Chain Reaction / Sequence Analysis, DNA / sericulture / Sex Characteristics / sex determination analysis / Silk / Silk - biosynthesis / Silkworms / Tetracycline - pharmacology / Trans-Activators - metabolism / transactivators / Transgenic animals / Transgenic insects / Worms

2013

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Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

by Fu, Guoliang , Huang, Yongping , Tan, Anjiang , Alphey, Luke , Meng, Zhiqi , Morrison, Neil I. , Niu, Baolong , Guo, Qiuhong , Jin, Li , Li, Zhiqian

2013

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Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

by Fu, Guoliang , Huang, Yongping , Tan, Anjiang , Alphey, Luke , Meng, Zhiqi , Morrison, Neil I. , Niu, Baolong , Guo, Qiuhong , Jin, Li , Li, Zhiqian

2013

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Journal Article

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

Fu, Guoliang,

Huang, Yongping,

Tan, Anjiang,

Alphey, Luke,

Meng, Zhiqi,

Morrison, Neil I.,

Niu, Baolong,

Guo, Qiuhong,

Jin, Li,

Li, Zhiqian

2013

Overview

Transgene-based genetic sexing methods are being developed for insects of agricultural and public health importance. Male-only rearing has long been sought in sericulture because males show superior economic characteristics, such as better fitness, lower food consumption, and higher silk yield. Here we report the establishment of a transgene-based genetic sexing system for the silkworm, Bombyx mori . We developed a construct in which a positive feedback loop regulated by sex-specific alternative splicing leads to high-level expression of the tetracycline-repressible transactivator in females only. Transgenic animals show female-specific lethality during embryonic and early larval stages, leading to male-only cocoons. This transgene-based female-specific lethal system not only has wide application in sericulture, but also has great potential in lepidopteran pest control.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

alternative splicing

/ Alternative Splicing - genetics

/ Animals

/ Biological Sciences

/ Bombyx - genetics

/ Bombyx - physiology

/ Bombyx mori