Journal Article

A case report of an M protein-negative patient with POEMS syndrome associated with renal involvement

Hou, Shuang, Liu, Wenlin, Li, Lingyan, Zhou, Yue, Zhang, Fan, Xiong, Zuying

2024

Overview

Background POEMS syndrome with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes is an uncommon plasma cell paraneoplastic syndrome involving multiple system. It is relatively rare in clinical practice, and renal involvement is a usual yet easily overlooked symptom. Case presentation We successfully treated a patient with M protein-negative POEMS syndrome with membranoproliferative glomerulonephritis (MPGN) findings and thrombotic microangiopathic changes by comparing the level of Vascular endothelial growth factor (VEGF) in the serum and the changes in polyserositis before and after the patient’s treatment. Conclusion POEMS syndrome clinically involves multiple systems and has complex symptoms. Because of the diversity of the disease manifestations, identification of atypical POEMS syndrome and timely intervention are important for patient survival and prognosis.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Autoimmune diseases / Biopsy / Case Report / Case reports / Case studies / Cell growth / Creatinine / Disease / Edema / Endocrine disorders / Glomerulonephritis / Glomerulonephritis, Membranoproliferative - complications / Humans / Hyperplasia / Internal Medicine / Kidney lymphatics / Lymphatic system / M protein / Male / Medical treatment / Medicine / Medicine & Public Health / Microscopy / Middle Aged / Nephrology / Paraneoplastic syndrome / Paraneoplastic syndromes / Patients / Peripheral neuropathy / Plasma / Plasma cell diseases / POEMS syndrome / POEMS Syndrome - blood / POEMS Syndrome - complications / POEMS Syndrome - diagnosis / Polyneuropathy / Polyserositis / Proteins / Renal damage / Vascular endothelial growth factor / Vascular Endothelial Growth Factor A - blood / VEGF