Journal Article

Correlation between hyperuricemia and thickened left ventricular wall in hypertensive young adults

Wu, Gaojun, Fang, Danhong, Wang, Na, Chen, Xiaoli, Lin, Weihong

2024

Overview

Background In this study, we examine the association between the hyperuricemia(HU) and hypertension(HTN) in Chinese young adults. Besides, the correlation between the occurrence of thickened left ventricular wall and HU was identified in patients with HTN. Methods In all, 360 patients with HTN and 1991 young adults with normal blood pressure(NBP) were enrolled in the study. Participant characteristics were collected. Univariable and multivariable logistic regression tests were utilized to identify the correlation between the presence of HU and HTN, and the correlation between the occurrence of thickened ventricular septum and HU in patients with HTN. Results The prevalence of HU in Chinese young adults with HTN was significantly higher than young adults with NBP(36.39% vs. 16.93%). Univariable analyses revealed that 8 factors were related with the presence of HTN with p value < 0.001, including HU, male, body mass index(BMI) ≥ 24 kg/m 2 , total cholesterol(TC) > 5.17mmol/L, triglyceride(TG) > 1.70mmol/L, high density lipoprotein cholesterol(HDL-C) < 1.0mmol/L, fasting blood glucose(FBG) > 6.10mmol/L and fatty liver. After adjusting these covariates, multivariable analysis revealed that HU[odds ratio(OR):1.47, 95% confidence interval(CI): 1.10–1.95, p  = 0.008] remained independent association with HTN in young adults. Additionally, univariable and multivariable logistic analyses revealed that HU kept the independent effect on the presence of thickened interventricular septum(adjusted OR = 1.81, 95% CI: 1.05–3.11, P  = 0.03) and thickened left ventricular posterior wall(adjusted OR = 2.28, 95% CI: 1.28–4.08, P  = 0.005) in young adults with HTN. Conclusion HU was independently associated with HTN in young adults. HU was independently correlated with thickened left ventricular wall, including interventricular septum and left ventricular posterior wall, in young adults with HTN.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Age Factors / Angiology / Automation / Biomarkers - blood / Blood Pressure / Blood sugar / Blood tests / Blood Transfusion Medicine / Body mass index / Cardiac Surgery / Cardiology / Cardiovascular disease / China - epidemiology / Cholesterol / Cross-Sectional Studies / Demographic aspects / Development and progression / Ejection fraction / Fatty liver / Female / Health aspects / Heart / High density lipoprotein / Homocysteine / Hospitals / Humans / Hypertension / Hypertension - diagnosis / Hypertension - epidemiology / Hypertension - physiopathology / Hypertrophy, Left Ventricular - diagnostic imaging / Hypertrophy, Left Ventricular - epidemiology / Hypertrophy, Left Ventricular - physiopathology / Hyperuricemia / Hyperuricemia - blood / Hyperuricemia - diagnosis / Hyperuricemia - epidemiology / Internal Medicine / Interventricular septum thickness / Left ventricular posterior wall thickness / Liver / Liver diseases / Male / Medical profession / Medicine / Medicine & Public Health / Mortality / Normal distribution / Obesity / Overweight / Prevalence / Pulmonary arteries / Regression analysis / Review boards / Risk Assessment / Risk Factors / Septum / Teenagers / Thyroid gland / Uric acid / Uric Acid - blood / Ventricle / Ventricular Function, Left / Ventricular Remodeling / Weight control / Young Adult / Young adults / Youth