Journal Article

Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese Population

Wang, Bei, He, Xingwei, Gao, Bo, Tan, Rong, Li, Zhuxi, Zeng, Hesong, Liu, Xintian, Wang, Tao, Liu, Yujian, Liu, Wanjun

2015

Overview

It is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection (AD). The aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population. A hospital-based case-control study, consisting of 2160 AD patients and 4320 controls, was conducted in a Chinese population. Demographic, clinical characteristics and risk factors were collected. Diabetes rate of patients with overall AD, Stanford type A AD and type B AD group was compared with that of corresponding matched control groups. Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI) for relationship between diabetes and AD risk. The prevalence of diabetes was lower in AD cases than that of control subjects, whether it is the overall AD, type A AD or type B AD group (4.7% vs. 10.0%, 2.9% vs. 8.8%, 5.9% vs. 10.9%, all P<0.001). Furthermore, in multivariate model, diabetes was found to be associated with lower AD risk, which not only applies to the overall AD (OR = 0.2, 95%CI: 0.15-0.26), but also type A AD (OR = 0.12, 95% CI: 0.07-0.20) and type B AD (OR = 0.25, 95%CI: 0.18-0.33). We observed the paradoxical inverse relationship between DM and risk of AD in the Chinese population. These results suggest diabetes may play a protective role in the development of AD. However, further studies are needed to enrich related evidence, especially with regard to underlying mechanisms for these trends.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Abdomen / Adolescent / Adult / Aged / Aged, 80 and over / Aneurysm, Dissecting - epidemiology / Aneurysm, Dissecting - ethnology / Aneurysms / Animals / Aorta / Aortic Aneurysm - epidemiology / Aortic Aneurysm - ethnology / Aortic dissection / Asian Continental Ancestry Group / Atherosclerosis / Autophagy / Cardiology / Cardiovascular disease / Cardiovascular diseases / Case studies / Case-Control Studies / China - epidemiology / Comorbidity / Confidence intervals / Control methods / Coronary vessels / Demographics / Diabetes / Diabetes mellitus / Diabetes Mellitus - epidemiology / Diabetes Mellitus - ethnology / Dissection / Ethics / Female / Health risks / Heart / Heart diseases / Hospitals / Humans / Hyperglycemia / Hypertension / Logistic Models / Male / Marfan syndrome / Middle Aged / Mortality / Multivariate Analysis / Odds Ratio / Patients / Population / Population studies / Prevalence / Regression analysis / Risk analysis / Risk Factors / Science / Statistical analysis / Studies