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The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
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The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
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Journal Article
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
2011
Overview
T-box transcription factor Eomes acts during gastrulation to promote mesoderm migration and specification of the definitive endoderm. Robertson and colleagues report a further role for Eomes in directing the specification of the cardiac lineage through activation of Mesp1 upstream of the cardiac transcriptional machinery at the gastrulation stage.
Instructive programmes guiding cell-fate decisions in the developing mouse embryo are controlled by a few so-termed master regulators. Genetic studies demonstrate that the T-box transcription factor Eomesodermin (Eomes) is essential for epithelial-to-mesenchymal transition, mesoderm migration and specification of definitive endoderm during gastrulation
1
. Here we report that
Eomes
expression within the primitive streak marks the earliest cardiac mesoderm and promotes formation of cardiovascular progenitors by directly activating the bHLH (basic-helix-loop-helix) transcription factor gene
Mesp1
upstream of the core cardiac transcriptional machinery
2
,
3
,
4
. In marked contrast to
Eomes/Nodal
signalling interactions that cooperatively regulate anterior–posterior axis patterning and allocation of the definitive endoderm cell lineage
1
,
5
,
6
,
7
,
8
, formation of cardiac progenitors requires only low levels of
Nodal
activity accomplished through a
Foxh1/Smad4
-independent mechanism. Collectively, our experiments demonstrate that
Eomes
governs discrete context-dependent transcriptional programmes that sequentially specify cardiac and definitive endoderm progenitors during gastrulation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Biomedical and Life Sciences
/ Embryo, Mammalian - embryology
/ Embryo, Mammalian - metabolism
/ Embryos
/ Female
/ Green Fluorescent Proteins - genetics
/ Green Fluorescent Proteins - metabolism
/ Kinases
/ letter
/ Male
/ Mice
/ Reverse Transcriptase Polymerase Chain Reaction
/ Sequence Homology, Nucleic Acid
/ T-Box Domain Proteins - genetics
