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Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
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Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
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Journal Article
Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
2019
Overview
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.
Lifestyle factors such as smoking and exercise contribute to the health of the brain during aging, but previous studies have focused on the effects of single lifestyle variables. Here, the authors examine the combined and individual effects of four lifestyle variables on brain structure and function.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ 631/378
/ Adults
/ Aged
/ Aging
/ Alcohol
/ Alcohol Drinking - adverse effects
/ Alcohols
/ Brain
/ Exercise
/ Female
/ Genetic Predisposition to Disease - genetics
/ Humanities and Social Sciences
/ Humans
/ Magnetic Resonance Imaging - methods
/ Male
/ Prefrontal Cortex - pathology
/ Science
/ Smoking
