Journal Article

Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium

Walwyn, Thomas, Chang, Kay W, Hudson, Melissa M, Weiss, Annette, Cohn, Richard J, Scheinemann, Katrin, van Dalen, Elvira C, Clemens, Eva, Langer, Thorsten, Skinner, Roderick, Kuehni, Claudia E, Constine, Louis S, Carleton, Bruce, Knight, Kristin, Orgel, Etan, Nathan, Paul C, Prasad, Pinki K, Caron, Eric, Brock, Penelope R, Rottenberg, Jan, Landier, Wendy, am Zehnhoff-Dinnesen, Antoinette, Kremer, Leontien C M, Brooks, Beth, van den Heuvel-Eibrink, Marry M, Bass, Johnnie K, Mulder, Renée L, Johnston, Karen, de Vries, Andrica C H, Bonne, Nicolas-Xavier, Bardi, Edith

2019

Overview

Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity (hearing loss, tinnitus, or both). To ensure optimal care and reduce consequent problems—such as speech and language, social–emotional development, and learning difficulties—for these CAYA cancer survivors, clinical practice guidelines for monitoring ototoxicity are essential. The implementation of surveillance across clinical settings is hindered by differences in definitions of hearing loss, recommendations for surveillance modalities, and remediation. To address these deficiencies, the International Guideline Harmonization Group organised an international multidisciplinary panel, including 32 experts from ten countries, to evaluate the quality of evidence for ototoxicity following platinum-based chemotherapy and head or brain radiotherapy, and formulate and harmonise ototoxicity surveillance recommendations for CAYA cancer survivors.

• Publisher: Elsevier Ltd,Elsevier Limited,Elsevier
• Subject: Adolescence / Adolescent / Age / Agreements / Antineoplastic Agents - adverse effects / Antineoplastic Agents - therapeutic use / Brain cancer / Cancer / Cancer Survivors - statistics & numerical data / Cancer therapies / Chemotherapy / Child / Childhood / Children / Children & youth / Clinical medicine / Collaboration / Consortia / Cranial Irradiation - adverse effects / Delivery of Health Care - standards / Education / Epidemiology / Evidence-Based Medicine / Experts / Hearing aids / Hearing loss / Hematology / Hematology, Oncology, and Palliative Medicine / Humans / Intervention / Leukemia / Life Sciences / Neoplasms - drug therapy / Neoplasms - radiotherapy / Oncology / Otolaryngology / Ototoxicity / Ototoxicity - diagnosis / Ototoxicity - etiology / Ototoxicity - prevention & control / Ototoxicity - therapy / Platinum / Platinum Compounds - adverse effects / Population Surveillance / Radiation therapy / Social discrimination learning / Studies / Surveillance / Teenagers / Tinnitus / Tumors / Young Adult / Young adults